Cristin Milioti’s portrayal of the ruthless Sofia Falcone in The Penguin might seem like a departure for her. But Cristin tells Marc her goal has always been to avoid being pigeonholed. Also, the tone of The Penguin is so theatrical and operatic that Cristin fit right in as someone who, in her words, was saved by theater kids in high school. They also talk about her run on Broadway in Once, the fear she had while making The Wolf of Wall Street, and the heartbreak of having an entire two-season series, Made for Love, deleted from existence.

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Perhaps a reason there’s always tension between Mike Birbiglia and Marc is they have a lot in common. That’s also probably the reason that, despite this tension, Mike has made multiple trips to the garage. This time, Mike and Marc talk about the job of making people laugh about things that make them sad or angry, the benefits and risks of centering your comedy around your personal life, and how they’ve both made peace with their doctor dads, with Mike dealing with it in his new Netflix special, The Good Life.

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Seth Meyers doesn’t get out to LA very often, but when he does he’s able to visit longtime friends, go on other late night shows, and head over to the garage to talk with Marc. This time they get into how Late Night is helping Seth process what’s going on in the world even has he helps viewer do the same. They also talk about SNL 50, including Seth’s interaction with Keith Richards and why Eddie Murphy and Will Ferrell are the greatest. Then they spend the rest of the time fanboying about Nathan Fielder and Tim Robinson.

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Josh Homme manifested an 18-year-old dream to perform a Queens of the Stone Age concert in the Catacombs of Paris. Josh tells Marc why it was such a meaningful undertaking two years after he survived a bout with cancer. They also talk about his collaborations and friendship with Iggy Pop, the 2015 terrorist attack during an Eagles of Death Metal concert, and the difference between giving up and giving in.

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John Mulaney has been through a lot since the last time he was on the show, so it’s nice he can identify the present as, in his words, a happy time that he can appreciate. John offers Marc his reflections on the first run of his Netflix talk show Everybody’s Live, reflections on his sobriety five years after everything fell apart, and reflections on the history of WTF, a show he was listening to right from the beginning.

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Scott Frank is one of Hollywood’s most prolific screenwriters but he still has perpetual anxiety about his job security. Scott and Marc talk about the impulse that keeps him grinding away, whether he’s working on original screenplays, rewrites, or his limited series like Godless, The Queen’s Gambit and his new Netflix show Department Q. They also talk about Scott’s mentors, his influences, and the construction of his most well known screenplays, like Get Shorty, Out of Sight, Minority Report, and Logan.

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Nick Kroll was one of the first dozen guests on WTF and in the nearly sixteen years of his life since then, loved ones have been lost, babies have been welcomed to the world, and Nick can now see things about himself that he couldn’t identify before. Nick and Marc talk about those changes, as well as the artwork of his wife Lily Kwong, the trip to Italy he made for his new movie I Don’t Understand You, and the fulfillment of creating eight seasons of Big Mouth.

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Peter Wolf didn’t want to write the typical rock and roll memoir filled with lurid tales and score settling. Instead he wanted to write a collection of short stories that stem from his serendipitous encounters with everyone from Marilyn Monroe to David Lynch. Peter tells Marc how he wrestled with his own memories to write the book, how he drew from his friendships with Bob Dylan, Muddy Waters and John Lee Hooker, and how he got right with the topics he wanted to avoid, namely his time with The J. Geils Band and his marriage to Faye Dunaway.

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Sarah Silverman and Marc go back more than 30 years and although they know a lot about each other from the past, they can both acknowledge that they haven’t stopped growing and learning and changing right up to the present. Sarah and Marc talk about making peace with the signs of aging, including hearing loss, and how an embrace of closure helped her deal with the loss of her father and stepmother, which is the center of her new Netflix special, PostMortem.

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Carol Leifer has been a standup comic for almost 50 years, but the knowledge she can impart from her lifetime of experience isn’t limited to the standup stage. That’s why Carol co-wrote the new book How to Write a Funny Speech, applying the building blocks of comedy to weddings, graduations and anywhere else one might speak in public. Carol and Marc talk about how to be funny at a memorial, her experience writing for the recent Oscars, and how she’s tapped into the current zeitgeist thanks to her teenage son.

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